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The Why Behind Our Work

We imagine a world where people living with genetic diseases can fully benefit from the promise of genetic medicines. Our novel mRNA and gene correction therapeutics have the potential to make this a reality.

Therapeutic Areas of Focus
  • Cystic fibrosis
  • Primary ciliary dyskinesia
  • Certain cancers and central nervous system (CNS) diseases

“Following the worldwide positive impact of the mRNA COVID-19 LNP vaccines, it is an exciting time to consider the future of LNP delivery technologies. ReCode is taking this concept to the next level with our SORT LNP technology that can deliver a wide variety of genetic medicines, each one safely packaged in novel lipid carriers designed to reach the target organs and cells throughout the body that need treatment.”

—Dan Siegwart, Ph.D.,
ReCode Co-Founder

Our Story Begins with Pioneering Research

ReCode co-founder, Professor Daniel J. Siegwart, Ph.D., of the University of Texas, has spent more than a decade engineering a modular delivery platform capable of packaging and delivering genetic medicine cargoes directly to the cells most impacted by disease. Now, the first-in-class selective organ targeting (SORT) lipid nanoparticle (LNP) platform is the foundation of our growing pipeline of genetic medicines.

Leadership

We’ve assembled an experienced team with substantial genetic medicines, orphan drug development, and technology development expertise from small and large biopharma companies.

David J. Lockhart, Ph.D.

President & Chief Scientific Officer

Angèle Maki, Ph.D.

Senior Vice President, Business Development

Brandon A. Wustman, Ph.D.

Senior Vice President, R&D

Nick P. France, M.D.

Senior Vice President, Clinical Development

Vladimir G. Kharitonov, Ph.D.

Senior Vice President, CMC

Investors

Shehnaaz Suliman, M.D., M.B.A., M.Phil.

Chief Executive Officer

Dr. Suliman is a physician, drug developer and dealmaker with over 25 years of experience building and transforming small and large biopharmaceutical companies.

Prior to becoming CEO of ReCode Therapeutics in January 2022, she served as president and chief operating officer of Alector, a leading immuno-neurology and immuno-oncology company where she played a critical role growing, scaling, raising capital and advancing a late-stage development pipeline.

Prior to Alector, she served as senior vice president, corporate development and strategy at Theravance Biopharma from 2017 to 2019, where she helped deliver a $1B profit sharing partnership with Janssen for the company’s lead JAK inhibitor program.

Prior to Theravance, Dr. Suliman was vice president and global head, immunology, infectious diseases and specialty care at Roche from 2015 to 2017. Dr. Suliman worked for Genentech as a group leader and project team leader in the R&D Portfolio Management and Operations Group from 2010 to 2015, where she oversaw an early development portfolio of more than 30 programs across multiple therapeutic areas. She held various management roles of increasing responsibility at Gilead Sciences, Inc. between 2005 and 2010 and played a significant role in forward-integrating Gilead into new therapeutic areas through M&A. Prior to Gilead, Dr. Suliman was an investment banker with Lehman Brothers and Petkevich & Partners, advising numerous public and private companies on buy- and sell-side transactions.

She was named one of the 2017 Fiercest Women in Life Sciences and as one of the National Diversity Council’s Power 50 in 2021 (Most Influential Women in Business). Dr. Suliman serves as an independent director on the Board of Directors of Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE) and 10x Genomics (NASDAQ: TXG). Dr. Suliman received her M.D. (MB, ChB) from the University of Cape Town Medical School, South Africa, and holds an MBA, with distinction, and M.Phil. degrees from Oxford University, where she was a Rhodes Scholar.

David J. Lockhart, Ph.D.

President & Chief Scientific Officer

Dr. Lockhart is an accomplished biotech executive with more than 25 years of experience across all phases of drug discovery, drug development and technology development.

Prior to becoming president and CSO of ReCode Therapeutics in January 2022, he served as CEO and president of the company since March 2020. Prior to serving as CEO and president of ReCode, he was CEO and president of its predecessor, TranscripTx from 2014 – 2020. Prior to TranscripTx, he was the Chief Scientific Officer at Amicus Therapeutics from 2006 through 2013. He led a team at Amicus that brought multiple rare disease programs into clinical trials.

Previously, he co-founded Ambit Biosciences, serving as Chief Scientific Officer and president for 5 years, during which the company developed a novel kinase profiling technology and new kinase inhibitors for cancer and other diseases. Prior to Ambit, Dr. Lockhart served as Director of Genomics at the Genomics Institute of the Novartis Research Foundation (GNF). Dr. Lockhart began his biotech career at Affymetrix, where he was the primary inventor and developer of gene expression profiling with DNA microarrays.

Dr. Lockhart received his Ph.D. in Chemistry from Stanford University and was a postdoctoral fellow at the Whitehead Institute in the Biology Department at MIT. He has published more than 80 peer-reviewed scientific articles on pharmacological chaperones, mutation-specific selection of patients for clinical trials, clinical studies with pharmacological chaperones, genomics, kinase technology, kinase inhibitor discovery, and the use of genomic tools to address important biological and biomedical problems. He is also the inventor on more than 40 issued U.S. patents.

Angèle Maki, Ph.D.

Senior Vice President, Business Development

Dr. Maki is an accomplished business development executive with nearly 20 years of deal-making and corporate development experience at both small biotechnology and large pharmaceutical companies.

Dr. Maki previously served as vice president, venture science, corporate business development at Eli Lilly, where she was responsible for setting strategy and sourcing innovative science and therapeutics for Lilly in the Bay Area. Prior to Lilly, she held business development leadership roles with increasing responsibility starting at Medarex, followed by BMS (which acquired Medarex), Genentech, 23andMe, and Merck & Co. During her career, she has successfully led diligence and negotiations on numerous in- and out-licensing transactions, from early-stage research technologies to clinical-stage assets.

Dr. Maki earned a Ph.D. in biological chemistry from Stanford University, completed postdoctoral work in molecular biology at The Scripps Research Institute in La Jolla, California, and received a B.S. in chemistry from the University of Winnipeg in Canada.

Brandon A. Wustman, Ph.D.

Senior Vice President, R&D

Dr. Wustman is a seasoned R&D executive with experience throughout his nearly 20-year career across many phases of R&D including discovery, clinical development, and the launch of new therapeutic platforms.

Prior to joining ReCode Therapeutics (and its predecessor, TranscripTx) in 2015, he had positions of increasing responsibility, including senior director, Preclinical Biology, at Amicus Therapeutics from 2002 to 2014. At Amicus, Dr. Wustman established a new lab focused on protein therapeutic discovery and production. He was also instrumental in leading the discovery and preclinical development of pharmacological chaperones used alone and in combination with enzyme replacement therapies for seven different preclinical programs.

Dr. Wustman received his B.S. and Ph.D. from Michigan Technological University. He was an Alexandar Humboldt Fellow at the University of Cologne, Germany and a postdoctoral fellow at New York University from 2000 to 2002. Dr. Wustman has published more than 20 peer-reviewed scientific articles and is also the inventor on nine issued U.S. patents.

Nick P. France, M.D.

Senior Vice President, Clinical Development

Dr. France is an accomplished rare disease clinical drug developer with extensive clinical, regulatory and business development expertise across all phases of development.

He previously served as vice president and head of clinical research at ESCAPE Bio, where he helped lead the transformation of the company from a preclinical to a clinical organization and had responsibility for all aspects of global clinical development and translational medicine. Prior to ESCAPE, Dr. France held positions of increasing responsibility in global biopharma organizations with a focus on developing clinical and regulatory strategy and building high performing clinical groups in emerging and early-stage biotech companies. He was senior director, clinical development for neurosciences and rare diseases with Roivant Sciences and Axovant Sciences, and executive director, clinical development at Strongbridge Biopharma. Other prior roles included global clinical program director at CSL Behring, and clinical development director, neurosciences and rare diseases at GlaxoSmithKline. During his career, Dr. France has successfully led a number of clinical programs through regulatory meetings for pivotal stage studies and has served in clinical leadership roles on the development of several assets that achieved regulatory approval including migalastat, AFSTYLA and Retigabine. He currently serves as a scientific medical advisory board member for the INADCure Foundation.

Dr. France earned a B.S. in pharmacology from King’s College London (University of London) in the U.K. and his M.D. from the University of Warwick Medical School (U.K.) after which he trained in Pediatrics in London with a focus on Intensive Care Medicine. Dr. France is also a member of the Royal College of Pediatrics and Child Health.

Vladimir G. Kharitonov, Ph.D.

Senior Vice President, CMC

Dr. Kharitonov is a senior executive with over 25 years of experience in pharmaceutical research and development, operational management, engineering and commercial manufacturing of pharmaceutical drug products.

Prior to joining ReCode Therapeutics in 2020, he held positions of increasing responsibility at Pacira Pharmaceuticals from 2000 through 2020 including vice president of Research and Development since 2010. He led a team at Pacira focused on all aspects of Chemistry, Manufacturing and Controls (CMC), including formulation, analytical, process and nonclinical development that brought three liposomal products in the pain management and cancer treatment spaces through regulatory approvals in the U.S. and EU. Throughout his career he also led engineering, technology transfer and commercial manufacturing teams both, on-site and at CMO.

Dr. Kharitonov received his Ph.D. in Chemistry from Moscow State University and was a visiting scientist and faculty member at the Department of Medicine at the University of California, San Diego. He has published more than 40 peer-reviewed scientific articles on mechanisms of chemical reactions, biochemistry and biochemical kinetics.

Trisha Millican
ReCode Therapeutics

Ms. Millican has over 20 years of experience in the life science industry including debt and equity financings, mergers and acquisitions, company formation, licensing transactions, co-development/promotional arrangements, and commercial product launches. Currently, Ms. Millican is a strategic advisor to various life science companies and serves on the board of Life Science Cares, San Diego. Most recently Ms. Millican served as the chief financial officer of Metacrine, Inc. where she led finance and investor relations and raised over $250 million in equity and debt financings including an initial public offering. Prior to Metacrine, Ms. Millican served as the senior vice president of finance at Seragon, a private biotechnology company focused on developing selective estrogen receptor degraders (SERDs) targeting hormone-dependent cancers, which was acquired by Genentech in August 2014.

From July 2012 to August 2013, she served as vice president of finance at Aragon, a discovery-stage small molecule company focused on therapeutics for the treatment of hormone-resistant cancers, which was acquired by Johnson & Johnson in August 2013. From September 2009 to July 2012, Ms. Millican served in various senior financial management roles at Zogenix, Inc., a pharmaceutical company developing and commercializing innovative central nervous system therapies for people living with serious and life-threatening rare central nervous system disorders and medical conditions.

At the beginning of her professional career, Ms. Millican spent five years with the public accounting firm, Deloitte LLP. She holds a bachelor’s degree in Accountancy from the University of San Diego and is a certified public accountant in the state of California.

Daniel J. Siegwart, Ph.D.

Co-Founder, Advisor, Collaborator

Dr. Daniel J. Siegwart holds the W. Ray Wallace Distinguished Chair in Molecular Oncology Research at the University of Texas Southwestern Medical Center and is a co-founder of ReCode Therapeutics. He is an Associate Professor in the Department of Biochemistry, Department of Biomedical Engineering (BME), and Simmons Comprehensive Cancer Center (SCCC). He serves as the Director of the Program in Genetic Drug Engineering, Director of the Drug Delivery Program in BME, and Co-leader of the Chemistry and Cancer Program in the SCCC.

His research laboratory utilizes materials chemistry to enable targeted delivery of genomic medicines. He recognized that although great advances had been made in the delivery of short RNAs, the ideal chemical and formulation composition was poorly understood for longer RNA cargo such as messenger RNA. Their efforts led to an understanding of the essential physical and chemical properties of synthetic carriers required for therapeutic delivery of genomic medicines including siRNA, miRNA, tRNA, pDNA, and mRNA.

He has been at the forefront in the design of synthetic carriers for gene editing and has applied these technologies for correction of genetic diseases. The Siegwart lab reported the first non-viral system for in vivo CRISPR/Cas gene editing in December 2016. Recently, they developed Selective ORgan Targeting (SORT), which is the first and only strategy for predictable tissue specific mRNA delivery and gene editing. SORT lipid nanoparticles are systematically engineered to exclusively edit extrahepatic tissues and therapeutically relevant cell types. SORT is compatible with multiple gene editing techniques in targeted tissues.

He received a B.S. in Biochemistry from Lehigh University and a Ph.D. in Chemistry from Carnegie Mellon University with University Professor Krzysztof Matyjaszewski. He also studied as a Research Fellow at the University of Tokyo with Professor Kazunori Kataoka. He then completed a Postdoctoral Fellowship at MIT with Institute Professor Robert Langer and Professor Daniel G. Anderson. Dr. Siegwart has co-authored over 70 research publications, with an h-index of 39 and more than 7,800 citations.

Ed Hurwitz, J.D., M.B.A.

MPM Capital

Mr. Hurwitz, an accomplished biotech executive and investor, is a Managing Director at MPM Capital and serves as Chairman of MPM portfolio companies BioIntervene and Rekindle Therapeutics, and on the board of Dyne Therapeutics.

Prior to MPM, he was founder and Managing Director of Precision BioVentures, where he founded and seeded start-up biotechnology companies, including Viewpoint Therapeutics. As a director at Alta Partners, he led 12 successful investments including Applied Genetic Technologies Corporation, Avid Radiopharmaceuticals (acquired by Lilly), Calistoga Pharmaceuticals (acquired by Gilead), Cara Therapeutics, FoldRx Pharmaceuticals (acquired by Pfizer), MacroGenics and Taligen Therapeutics (acquired by Alexion).

Over the course of his career, he has been a Senior Vice President and CFO of Affymetrix, a microarray pioneer, and a biotech research analyst for Robertson Stephens & Company and Smith Barney Shearson. He also practiced law at Cooley Godward LLP.

He earned his J.D. and M.B.A. degrees from the University of California, Berkeley’s Boalt School of Law and Haas School of Business, and his B.A. in molecular biology from Cornell University.

Helen Kim, M.B.A.

Vida Ventures

Ms. Kim is a Managing Director of Vida Ventures, a life sciences focused venture capital firm.

Most recently, Ms. Kim was a Partner at The Column Group. Previously, she served as Executive Vice President of Business Development at Kite Pharma, Inc., where she led business and corporate development initiatives including selling Kite Pharma to Gilead in 2017. Previously, Ms. Kim served as Strategic Advisor of NGM Biopharmaceuticals, Inc. from January 2012 through November 2014; served as Chief Business Officer at NGM Biopharmaceuticals, Inc. from August 2009 to January 2012; served as Chief Executive Officer and President of Kosan Biosciences where she restructured and successfully assisted in selling the company to Bristol-Myers Squibb in 2008.

She received a B.S. in chemical engineering from Northwestern University and an M.B.A. from the University of Chicago. Ms. Kim is currently a director for Assembly Biosciences, Applied Molecular Transport, Exicure, Inc., A2 Biotherapeutics, Neogene and PACT.

Oleg Nodelman

EcoR1 Capital

Mr. Nodelman is the Founder and Portfolio Manager of EcoR1 Capital LLC, a biotech-focused investment advisory firm established in 2013, which invests in companies at all stages of research and development.

With twenty years of experience in biotech investing, Mr. Nodelman has expertise in all aspects of investment management and deep roots in the biotech and scientific communities. Before founding EcoR1, Mr. Nodelman was a portfolio manager at BVF Partners, one of the first hedge funds dedicated to the biotechnology sector. He currently serves as a Board Member for three publicly traded companies: Prothena (NASDAQ: PRTA), a clinical-stage neuroscience company, AnaptysBio (NASDAQ: ANAB), a clinical-stage biotechnology company focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, and Nuvation Bio (NYSE: NUVB), a clinical-stage biopharmaceutical company tackling unmet needs in oncology.

Mr. Nodelman has a Bachelor of Science in Foreign Service with a concentration in Science and Technology from Georgetown University.

RA Session II

Taysha Gene Therapies

Mr. Session II is the President, CEO and founder of Taysha Gene Therapies. Mr. Session has nearly 20 years of experience in the life sciences industry, primarily in business development, corporate strategy and financial roles. Previously, he served as Chief Business Officer of the gene therapy subsidiaries of BridgeBio, as well as Senior Vice President of Corporate Strategy and Business Development at AveXis.

Peter Thompson, M.D.

OrbiMed Advisors
Dr. Thompson is a partner on the private equity team at OrbiMed Advisors LLC. With over 25 years of industry experience, he has held executive positions at Becton-Dickinson and Chiron, co-founded and was CEO of Trubion Pharmaceuticals, co-founded Corvus Pharmaceuticals, Cleave Biosciences, Silverback Therapeutics and serves as a director on several company boards. Dr. Thompson is an Ernst & Young Entrepreneur of the Year awardee, an Affiliate Professor of Neurosurgery at the University of Washington, an inventor on numerous patents and a board-certified internist and oncologist. He was on staff at the National Cancer Institute following his internal medicine training at Yale University.

David J. Lockhart, Ph.D.

ReCode Therapeutics

Dr. Lockhart is an accomplished biotech executive with more than 25 years of experience across all phases of drug discovery, drug development and technology development.

Prior to becoming president and CSO of ReCode Therapeutics in January 2022, he served as CEO and president of the company since March 2020. Prior to serving as CEO and president of ReCode, he was CEO and president of its predecessor, TranscripTx from 2014 – 2020. Prior to TranscripTx, he was the Chief Scientific Officer at Amicus Therapeutics from 2006 through 2013. He led a team at Amicus that brought multiple rare disease programs into clinical trials.

Previously, he co-founded Ambit Biosciences, serving as Chief Scientific Officer and president for 5 years, during which the company developed a novel kinase profiling technology and new kinase inhibitors for cancer and other diseases. Prior to Ambit, Dr. Lockhart served as Director of Genomics at the Genomics Institute of the Novartis Research Foundation (GNF). Dr. Lockhart began his biotech career at Affymetrix, where he was the primary inventor and developer of gene expression profiling with DNA microarrays.

Dr. Lockhart received his Ph.D. in Chemistry from Stanford University and was a postdoctoral fellow at the Whitehead Institute in the Biology Department at MIT. He has published more than 80 peer-reviewed scientific articles on pharmacological chaperones, mutation-specific selection of patients for clinical trials, clinical studies with pharmacological chaperones, genomics, kinase technology, kinase inhibitor discovery, and the use of genomic tools to address important biological and biomedical problems. He is also the inventor on more than 40 issued U.S. patents.

Shehnaaz Suliman, M.D., M.B.A., M.Phil.

ReCode Therapeutics

Dr. Suliman is a physician, drug developer and dealmaker with over 25 years of experience building and transforming small and large biopharmaceutical companies.

Prior to becoming CEO of ReCode Therapeutics in January 2022, she served as president and chief operating officer of Alector, a leading immuno-neurology and immuno-oncology company where she played a critical role growing, scaling, raising capital and advancing a late-stage development pipeline.

Prior to Alector, she served as senior vice president, corporate development and strategy at Theravance Biopharma from 2017 to 2019, where she helped deliver a $1B profit sharing partnership with Janssen for the company’s lead JAK inhibitor program.

Prior to Theravance, Dr. Suliman was vice president and global head, immunology, infectious diseases and specialty care at Roche from 2015 to 2017. Dr. Suliman worked for Genentech as a group leader and project team leader in the R&D Portfolio Management and Operations Group from 2010 to 2015, where she oversaw an early development portfolio of more than 30 programs across multiple therapeutic areas. She held various management roles of increasing responsibility at Gilead Sciences, Inc. between 2005 and 2010 and played a significant role in forward-integrating Gilead into new therapeutic areas through M&A. Prior to Gilead, Dr. Suliman was an investment banker with Lehman Brothers and Petkevich & Partners, advising numerous public and private companies on buy- and sell-side transactions.

She was named one of the 2017 Fiercest Women in Life Sciences and as one of the National Diversity Council’s Power 50 in 2021 (Most Influential Women in Business). Dr. Suliman serves as an independent director on the Board of Directors of Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE) and 10x Genomics (NASDAQ: TXG). Dr. Suliman received her M.D. (MB, ChB) from the University of Cape Town Medical School, South Africa, and holds an MBA, with distinction, and M.Phil. degrees from Oxford University, where she was a Rhodes Scholar.

Arthur E. Johnson, Ph.D.

Advisor

Dr. Johnson is an Emeritus Regents’ Professor, Distinguished Professor of Molecular and Cellular Medicine and of Chemistry, and Wehner-Welch Chair at Texas A&M University. He co-founded ReCode Therapeutics and founded tRNA Probes, LLC. His primary research focus has been the production, modification and utilization of transfer RNA (tRNA) molecules for the past 50 years. He was the first to incorporate probes into nascent proteins during their synthesis, using chemically modified aminoacyl-tRNAs to examine protein synthesis, folding, and trafficking, both their insertion into membranes and translocation through membranes. He is responsible for a number of significant discoveries in these and other areas (e.g., pore-forming proteins, blood coagulation) based on the unique research techniques he originated.

He received a B.S. in Chemistry at the California Institute of Technology and a Ph.D. in Molecular Biology/Chemistry at the University of Oregon. After a postdoc in Biophysical Chemistry at Columbia University, he joined the Chemistry and Biochemistry faculty at the University of Oklahoma before moving to Texas A&M University in 1994. He has authored or co-authored over 170 full-length research publications, with an h-index of 75 and more than 17,200 citations.

Philip Thomas, Ph.D.

Co-Founder, Advisor

Dr. Thomas is the Ruth S. Harrell Professor of Medical Research in the Department of Physiology at the University of Texas Southwestern Medical Center. Since his arrival in Dallas in 1993, after a postdoctoral fellowship at Johns Hopkins University School of Medicine, he and his group have built on a thirty-five year-long interest in the molecular basis of disease and the translation of this knowledge to patients. This includes contributions to the understanding of genetic diseases owing to protein misfolding and basic knowledge of quality control systems relevant to these pathologies. At Hopkins, he initiated projects into elucidating the molecular pathology of cystic fibrosis, under the umbrella of the CF center. This work provided one of the first examples of protein misfolding as a basis of human disease, along with the suggestion that small molecule ligands might be used to counteract the effects of the most common CF-causing mutation, F508del. Dr Thomas was awarded the JHU Young Investigators award in 1992 for this early work. At UT Southwestern, Thomas and his collaborators defined the details of F508del misfolding and discovered the two-step mechanism that has supported the recent development of effective small molecule therapies that correct the F508del mutant CFTR and restore function. This work was previously recognized by an NIH MERIT award and more recently by the Paul di Sant’Agnese Distinguished Scientific Achievement Award. More recently, the group has led an effort to extend this work to rarer CF causing mutations and their responses to extant drugs, thereby providing “theratype” information for scores of genotypes composed of insufficient numbers to support clinical development. Many of Dr Thomas’ former trainees remain active in CF either as faculty or in commercial efforts to develop better treatments for CF. In addition to his position at UT Southwestern, Dr. Thomas is the senior Principal Scientist at the CFF Laboratory in Lexington Massachusetts and a co-founder of Reata Pharmaceuticals and ReCode Therapeutics, two companies actively translating basic work into new therapies.

Justin Hanes, Ph.D.

Scientific Advisory Board Member
Dr. Hanes is the Lewis J. Ort professor of ophthalmology at the Wilmer Eye Institute at Johns Hopkins University, with secondary appointments in chemical & biomolecular engineering, environmental health sciences, neurosurgery and oncology. A globally recognized leader of research at the interface of nanotechnology and medicine, Dr. Hanes focuses his research on the delivery of genetic medicines, characterization of mucus and design, and testing of nanoparticles that can penetrate mucus barriers. His lab recently discovered methods to make drug- and gene-loaded particles that efficiently penetrate mucus barriers, which may allow for more effective therapies for eye diseases.

Rakhshita Dhar, M.S.

Leaps by Bayer

Rakhshita Dhar is Senior Director of Venture Investments Health at Leaps by Bayer. She joined the team in 2021 and is responsible for search & evaluation and healthcare focused investment for Leaps. She currently sits on the board of Deka Biosciences, Gro Bio, AffiniT therapeutics, Bloom science and Edifice health.

Prior to joining Leaps, Rakhshita was Director of Business Development at Roche Pharmaceuticals where she led collaborations with Dyno Therapeutics and Rheos Biosciences. She also spent a few years at MassBio developing an accelerator program for life-science start-ups.

She got her Undergraduate degree in Biochemistry from Mumbai University and her Masters in Molecular Biology from Georgetown University.

Alan Colowick, M.D., M.P.H.

Matrix Capital Management Company

Alan Colowick is Senior Managing Director on the Technology-Life Sciences team at Matrix Capital Management Company, LP and its affiliate, AyurMaya Capital Management Company, LP. He currently also serves on the BODs of Acelyrin Inc, Alumis Therapeutics, Solve Therapeutics, Personalis, Inc., AC Immune SA, Harpoon Therapeutics, Inc., InCarda Therapeutics, Inc., XyloCor Therapeutics, and Teon Therapeutics, Inc. Prior to joining Matrix, Dr. Colowick was a Partner at Sofinnova Investments, where he was Chairman of the BOD of two portfolio companies and helped lead their successful acquisitions (Velos Bio acquired by Merck for $2.75B and Principia Inc acquired by Sanofi for $3.7B).

Prior to that, Dr. Colowick had an 18 year career in biotech including significant operating and executive roles at Amgen; Gloucester Pharmaceuticals, where he was CEO and led its acquisition by Celgene: and Celgene, where he was President of EMEA. Dr. Colowick received his MD from Stanford University and completed fellowship training in Hematology and Oncology at the Dana Farber Cancer Institute. He also holds an MPH from Harvard University.

Chris Pritchard, Ph.D., M.B.A.

Matrix Capital Management Company
Board Observer

Chris Pritchard is a Principal on the Technology-Life Sciences team at Matrix Capital Management Company, LP and its affiliate, AyurMaya Capital Management Company, LP.

Prior to joining Matrix, Dr. Pritchard was a Vice President at Sana Biotechnology, where he was responsible for business development and strategy leading to numerous successful partnerships, including with Beam and Fujifilm Cellular Dynamics for access to foundational gene editing and stem cell technologies.  He also served as a program team leader advancing two novel in vivo gene therapy programs in preclinical research and development.

Prior to Sana, Dr. Pritchard held business development roles at Genentech, resulting in successful acquisitions and clinical stage in-licensing partnerships across therapeutic areas.  He was also a project team leader at the Boston Consulting Group, advising major biopharma companies on strategy and operations.  Dr. Pritchard received his PhD from MIT under Dr. Robert Langer.  He also holds an MBA from MIT Sloan and a Masters from the University of Oxford.

Daniel J. Siegwart, Ph.D.

Chair of the Scientific Advisory Board
Dr. Siegwart is the W. Ray Wallace Distinguished Chair in Molecular Oncology Research and associate professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center and is a co-founder of ReCode Therapeutics. Dr. Siegwart has been a pioneer in the design of delivery technologies for genetic medicines. ReCode’s SORT LNP platform, developed by Dr. Siegwart and his lab, was described by Nature as one of the “Seven Technologies to Watch in 2022.” In 2016, his lab reported the first non-viral system for in vivo CRISPR/Cas gene editing. Dr. Siegwart and his research team are focused on solving challenges in disease therapy and diagnosis, with a focus on the development of new materials that can deliver genetic medicines to treat cancer and genetic diseases.

Rafael Amado, M.D.

Scientific Advisory Board Member
Dr. Amado serves as executive vice president of research and development at Allogene Therapeutics, Inc. He most recently served as president of research and development at Adaptimmune Therapeutics PLC, after serving as its chief medical officer. Previously, he held several roles of increasing responsibility at GSK, most recently as senior vice president and head of oncology research and development. Dr. Amado has built a career leading the development of a number of breakthrough therapies in hematology and oncology, with a focus on immunotherapies and CAR-T drug discovery and development.

Carrolee Barlow, M.D., Ph.D.

Scientific Advisory Board Member
Dr. Barlow was most recently the chief medical officer of Escape Bio, Inc. Prior to joining Escape Bio, she served as chief executive officer of the Parkinson’s Institute and Clinical Center. Dr. Barlow was also formerly acting chief medical officer at Amicus Therapeutics and was a co-founder, chief scientific officer and chief medical officer of BrainCells, Inc. She also served as director of molecular neuroscience at Merck Research Laboratories and was a professor at the Salk Institute. Dr. Barlow is an expert in neuroscience and neurodegeneration, the treatment of rare and neurological diseases and clinical development for new therapies.

Eric Olson, Ph.D.

Scientific Advisory Board Member
Dr. Olson is the founding chair of the department of molecular biology at the University of Texas Southwestern Medical Center. He also directs the Hamon Center for Regenerative Science and Medicine and the Wellstone Center for Muscular Dystrophy Research. He holds the Robert A. Welch Distinguished Chair, the Pogue Distinguished Chair and the Annie and Willie Nelson Professorship. Dr. Olson and his team discovered many of the genes that control heart and muscle development and disease. His most recent work has provided a new strategy for correction of Duchenne muscular dystrophy-causing mutations using CRISPR gene editing.

Elliott Sigal, M.D., Ph.D.

Scientific Advisory Board Member
Dr. Sigal currently serves as co-chair of the scientific advisory board for Amgen, Inc. and as a senior advisor to New Enterprise Associates, Inc. He is a member of the Board of Directors for Adaptimmune Therapeutics, Vir Biotechnology, Surface Oncology, Tessera Therapeutics and Affinia Therapeutics. He is a former executive vice president of Bristol Myers Squibb where he also served as chief scientific officer and president of research and development from 2004 until 2013. Under his leadership, BMS brought 14 new medicines to market and became a leading immuno-oncology company. In 2012, SCRIP Intelligence named Dr. Sigal the best R&D chief in the pharmaceutical industry.

Rana Al-Hallaq, Ph.D.

Pfizer Ventures

Dr. Al-Hallaq is Executive Director and Partner at Pfizer Ventures.

Dr. Al-Hallaq leverages her preclinical, clinical, and business development experience to assess, invest in, and manage equity investments for Pfizer Ventures. She currently has responsibility for Pfizer’s investments in Mitokinin, Inc. (San Francisco, CA), Autifony Therapeutics Ltd. (Stevenage, UK), Blade Therapeutics (South San Francisco, CA), RefleXion Medical (Hayward, CA), Montis (Leuven, Belgium), Biograph55 (San Francisco, CA), Vivet Therapeutics (Paris, France), and Arkuda (Cambridge, MA) among others.

Prior to her current role, Dr. Al-Hallaq was a Transactionalist in Worldwide Business Development at Pfizer where she was responsible for negotiating and transacting licenses, acquisitions, and partnerships across therapeutic areas. Dr. Al-Hallaq joined Pfizer in 2015 as an Early Candidate Clinical Lead where she advised early clinical programs in CNS to ensure alignment with business strategies. Prior to joining Pfizer, she held roles at Allergan (formerly Actavis, formerly Forest Laboratories), first in Clinical Development Psychiatry as scientific and operational lead on Phase 2 and Phase 3 studies investigating novel treatments for Major Depressive Disorder and schizophrenia, and later in Business Development where she assessed and executed on a number of acquisitions and licenses across therapeutic areas. She began her training as a research fellow at the National Institutes of Health (NIH).

Dr. Al-Hallaq graduated Summa Cum Laude and Phi Beta Kappa with a B.A. in Biology from Hamilton College and holds a Ph.D. in Neuroscience from Georgetown University Medical Center.